America’s youth are increasingly abusing common over-the-counter medications, according to records from poison centers. A health advisory from America’s Poison Centers has highlighted a significant rise in cases of diphenhydramine abuse among teens aged 13 to 19.
Diphenhydramine Abuse on the Rise
Diphenhydramine, found in allergy and sleep medications like Benadryl and Zzzquil, has seen a notable increase in abuse. Between 2024 and 2025, total exposure to substances among teens rose by 5.1%. Diphenhydramine cases spiked significantly, increasing from 10,068 to 13,284 cases. By 2026, 13% of these cases were linked to intentional misuse, up from 7.3% in 2020.
Intentional Abuse Concerns
In 2026, the first five months alone saw 6,179 diphenhydramine-only cases among teens, doubling from the previous year. America’s Poison Centers indicate that intentional abuse, rather than accidental over-medication, is driving this trend. This misuse poses significant health risks, affecting the brain and heart.
“Taking diphenhydramine improperly can lead to life-threatening effects,” warns the advisory.
Symptoms of poisoning include drowsiness, agitation, increased heart rate, nausea, vomiting, hallucinations, seizures, and loss of consciousness.
Recommendations for Safe Use
To prevent overexposure, America’s Poison Centers advises storing medications safely, out of children’s and teens’ reach. Follow label instructions precisely, and discuss misuse risks with teens.
Kenvue, Benadryl’s manufacturer, emphasizes that the health and safety of product users are a priority. They warn against social media trends promoting misuse and are collaborating with social media platforms to curb this dangerous behavior.
Mary Leonard of the Consumer Healthcare Products Association advises that over-the-counter (OTC) medicines should not be used recreationally. Misuse can lead to severe health effects. Proper use involves adhering to dosing instructions on the label.
Preventive Measures
- Report related social media content where it appears.
- Store OTC medicines securely, preferably in locked cabinets.
- Read and follow the label instructions and educate children on safe usage.
Kenvue’s spokesperson emphasizes consulting healthcare professionals for guidance on medication use.