May 22, 2026

Rare Quadruple Transplant Brings Hope for Cystic Fibrosis Patient

A Medical Breakthrough

Jasmine Jones faced a profound moment upon learning her doctors intended to replace four organs simultaneously. Her battle with cystic fibrosis had already been significant. Though initially numb to the news, a sense of calm enveloped Jones as she prepared for surgery. In January, a team from University of Chicago Medicine conducted her quadruple organ transplant, a novel procedure in Illinois. Jones received a new right lung, left lung, kidney, and liver from one donor over 36 hours, marking the sixth such case in the United States according to data from the United Network for Organ Sharing.

Post-Surgery Journey

Surgeon Dr. Rolf Barth described the procedure as pioneering. Five months later, Jones returned home feeling optimistic. Her recovery included weeks at a hospital followed by rehabilitation at the Shirley Ryan AbilityLab. Learning the rarity of her procedure brought mixed emotions. Her mother expressed relief that she hadn’t known beforehand. Despite lifelong challenges from cystic fibrosis, Jones had managed her symptoms modestly until her teen years.

Health Decline and Resilience

A decade ago, cystic fibrosis-related complications fragmented her health and mobility, forcing her to leave school. With medical intervention, her health stabilized, allowing her to pursue work as an assistant preschool teacher. Yet issues resurfaced, culminating in frequent infections and overwhelming fatigue. The severity of Jones’ condition led her doctors to propose the comprehensive transplant as a viable option.

Preparing for the Procedure

Jones’ acceptance of the situation came gradually. Discussions began with a liver transplant before escalating to include her failing kidneys and lungs. Due to ineffectiveness of CFTR modulators, her doctors planned an ambitious collective organ transplant. To Jones, the process seemed rapid and surreal. By December, doctors advised hospitalization for organ matching despite her desire to partake in cherished family traditions.

The Match

Jones joined a deceased donor transplant list, soon matched due to urgency and favorable prognosis. Her transplant priority accelerated, leading to a quick match. On surgery day, Jones sought spiritual support for her mother. Patricia Smith, anxious yet strong, found solace from a chaplain during the extensive procedures. A team of 40 medical professionals collaborated on the successive organ transplants.

Complex Procedures

Surgeons began lung removal and replacement, employing external blood circulation techniques to sustain Jones. The liver, maintained via a perfusion machine, followed next in line. Finally, her kidney transplant capped the intensive surgery. Jones endured discomfort and immobility post-operation, but her rapport with the medical team fostered resilience.

Returning to Life

By March, Jones transitioned back to her family home. Adjustments included lifelong immunosuppressive medication. Reuniting with her family and pets brought immense relief. Her medical team expressed admiration for her recovery, noting her return to normalcy as extraordinary. Although quadruple transplants remain rare, advances in medicine have extended life expectancy for severe cases.

Looking Forward

Jones reflects on her anonymous donor, expressing gratitude for her new lease on life. With revitalized energy and optimism, she anticipates pursuing career opportunities, hobbies, and family activities. Jones embraces the opportunities afforded by her groundbreaking transplant, cherishing the ability to engage fully with life.

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