Individuals classified as “high-risk” are advised to remain at home and reduce interaction with other people. They should avoid entering any buildings other than their residence and refrain from having visitors. Coordination with state or local health departments is necessary for any essential travel.

On May 15, 2026, the cruise ship Hondius experienced a hantavirus outbreak. The outbreak has led the Centers for Disease Control and Prevention to significantly tighten its advice for those at highest risk of exposure. The CDC has introduced more stringent measures, but some infectious-disease specialists express concerns that these may be challenging to implement.